Abundant Gut Bacteria in Crohn's Disease Linked to Spondyloarthritis
High levels of a type of E. coli found in patients with Crohn’s disease triggers inflammation associated with spondyloarthritis, according to a study published in Science Translational Medicine.
For the study, the investigators used flow cytometry to examine gut bacteria in fecal samples derived from patients with inflammatory bowel disease (IBD). Flow cytometry is a technology that uses fluorescent probes to detect immunoglobulin-A (IgA)-coated bacterial species.
The investigators discovered that IgA-coated E. coli were abundant in the fecal samples of patients with both Crohn’s disease and spondyloarthritis. Next, they used patient samples and mouse models to link the bacteria to Th17 cells, which help regulate inflammation in individuals with autoimmune disorders. Read more here.
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