ABSTRACT: Patients with inflammatory bowel disease (IBD) are at higher risk of septic and thromboembolic complications after surgery. While these patients’ cases are often complicated from a surgical perspective, we now also manage them with a variety of immunosuppressive agents that can increase the risk of postsurgical complications. Whether to withhold or continue these medications in the perioperative period is the subject of ongoing debate in the IBD surgical community.

An entirely new type of T-cell found in people with rheumatoid arthritis works in a unique way to drive disease processes in the joints by teaming up with other immune cells. The discovery of this T-cell, which is rare in other people, offers opportunities for research into more targeted treatment approaches that may turn out to be more effective and less prone to side effects than existing therapies.

A nearly $1.8 million grant given a research team at The Scripps Research Institute (TSRI) in Florida will be used to study an enzyme that controls cell survival and death, with the goal of developing drug candidates to treat inflammatory diseases like rheumatoid arthritis, and cardiovascular and neurodegenerative disorders. 

The US Food and Drug Administration (FDA) has approved immune globulin subcutaneous [human], 20% solution (Cuvitru) to treat adults and children aged 2 years and older who have primary immunodeficiency.

Patients who are prescribed oral methotrexate for treatment of autoimmune disorders should take the medication ____________________.

a. daily

b. weekly

c. twice a week

d. a or b

e. b or c

-----

Answer: e

By Will Boggs MD

NEW YORK (Reuters Health) - A variety of health maintenance issues faced by patients with inflammatory bowel disease (IBD) require joint management by the gastroenterologist and the primary care team, according to a new clinical guideline from the American College of Gastroenterology.

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases in the country with total health care costs approaching $19 billion each year. Over time, the chronic inflammation, left unabated can lead to progression of joint disease and irreversible destruction. The key to successfully treating this dreaded disease is to rapidly control the illness and maintain control.

Patients diagnosed with psoriasis or psoriatic arthritis (PsA) are at an elevated risk for fracture and osteoporosis compared to the general population and patients with rheumatoid arthritis, according to a recent study by Ogdie and colleagues.1

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Research recently presented at the 2016 Advances in IBD Conference showed that more than one-fifth of patients who were prescribed biologic therapy for inflammatory bowel disease were nonadherent.

Results of a multinational, randomized, equivalence study show that the investigational biosimilar PF-06410293 demonstrates equivalent efficacy to the biologic Humira (adalimumab; AbbVie) in patients with severe to moderate rheumatoid arthritis (RA) who had an inadequate response to methotrexate therapy.

Called REFLECTIONS B538-02, the study was undertaken to evaluate the efficacy, safety, and immunogenicity of PF-06410293 compared to the biologic Humira in patients with moderate to severe RA.

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